• br Acknowledgements This work was supported by the FedEx Ins

  2023-03-17

  

  Acknowledgements This work was supported by the FedEx Institute of Technology at The University of Memphis (to DLB and ALP), NSF REU CHE 1156738 (to ALP in support of RSS), and NIHCA921060 (to GT). This material is based upon work supported by the National Science Foundation under Grant No. CHE-1

• br Materials and methods br Results To explore

  2023-03-17

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the Stattic of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression of p62 was revealed t

• calcium calmodulin dependent protein kinase TUNEL assay Apop

  2023-03-17

  

  TUNEL assay. Apoptotic DNA fragmentation in calcium calmodulin dependent protein kinase was measured using a commercially available TUNEL assay kit (Thermo Fisher). Frozen cells were fixed with 10% paraformaldehyde/PBS. Apoptosis was determined by staining the 3′-OH ends of fragmented DNA with bioti

• The results of our in vivo experiments provide promising

  2023-03-17

  

  The results of our in vivo experiments provide promising evidence that the apelin/APLNR axis is implicated in CCA growth and that targeting this axis with a receptor specific antagonist may help develop effective, tumor directed therapies. Not only do we show decreased proliferation and angiogenesis

• br Nanoparticle Conjugated Topoisomerase Inhibitors The safe

  2023-03-17

  

  Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5

• br Funding br Introduction Plants absorb both inorganic

  2023-03-17

  

  Funding Introduction Plants absorb both inorganic nitrogen (ammonium and nitrate) and organic nitrogen (amino acids and peptides) from the soil [1]. The first organic nitrogenous molecule produced from inorganic nitrogen is Gln, whose terminal amino group is successively transferred to make Gl

• HT modulates cortical and hippocampal pyramidal cell

  2023-03-17

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal R547 as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 2015, Da

• br Conclusions and clinical relevance Astrogliosis and an

  2023-03-17

  

  Conclusions and clinical relevance Astrogliosis and an increase in ADK is a pathologcial hallmark of epilepsy. The consequence of increased ADK in the epileptic C527 is a decrease in the ambient adenosine tone and A1R activity. As a result, systemic administration of A1R agonists or ADK inhibito

• br In patients with spina bifida

  2023-03-16

  

  In patients with spina bifida and spinal cord injury, fecal incontinence is a serious issue that can impair activities of daily living and patient self-esteem. To address this Malone et al. first described the Antegrade Continence Enema (ACE) procedure in 1990 [1], which achieves continence by all

• Autotaxin has been linked to chemoresistance through its abi

  2023-03-16

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer 3-bromo-5-phenyl Salicylic Acid [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being o

• Purification of Rv c In order to investigate the

  2023-03-16

  

  Purification of Rv2477c. In order to investigate the catalytic capabilities of Rv2477c, we expressed the protein as an N-terminal histidine-tagged fusion protein in E. coli BL21 cells and purified the protein by cobalt-affinity chromatography. As shown in Fig. 2A, the 65 kDa fusion protein was expre

• Although the role of apelin and APJ

  2023-03-16

  

  Although the role of apelin and APJ receptor in cardiovascular functions has been well-elucidated, little is known for the effect of the central apelinergic system on gastrointestinal (GI) functions. In mice, it has been found previously that central exogenous apelin-13 decreased gastric emptying (G

• The subnuclear localizations of redox regulators is also

  2023-03-16

  

  The subnuclear localizations of redox regulators is also largely unknown. The potential role of thiol reductases as transcription regulators or DNA repair molecules may suggest an association to DNA. In this way, the presence of a zinc finger domain potentially involved in protein/DNA interactions o

• However a high triglyceride level was associated with dement

  2023-03-15

  

  However, a high triglyceride level was associated with dementia in a study with subjects aged ≥65 years (Raffaitin et al., 2009). In another study, the serum triglyceride levels of three different transgenic mouse strains mimicking AD were also evaluated within the progression of the pathology. In o

• Estudos de biomarcadores mostram que as

  2023-03-15

  

  Estudos de biomarcadores mostram que as concentrações de proteína amiloide no LCR estão inversamente relacionadas com o grau de doença de Alzheimer. No entanto, quer as placas amiloides quer a diminuição da proteína amiloide podem ser encontradas em idosos sem clínica de disfunção cognitiva, pelo qu

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