• It was previously proposed that glucagon acts in the liver

  2022-06-20

  

  It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the UNC669 via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the liver but

• The molecular mechanisms underlying spindle orientation are

  2022-06-18

  

  The molecular mechanisms underlying spindle orientation are still largely unknown. Budding yeast has been used to study spindle positioning and asymmetric cell division. Indeed, after cytokinesis, daughter cells have different sizes. The cell division plane is established early in the cell cycle and

• The diseases of ocular surface and the cornea

  2022-06-17

  

  The diseases of ocular surface and the cornea are very common in ophthalmological practice and as a result there is a continuous, need for novel therapeutic options. Here, we demonstrated a corneal distribution of GPR35, a potential molecular target for new drugs (; ). The search for the expression

• br Introduction Cell surface receptors are central to the in

  2022-06-17

  

  Introduction Cell surface receptors are central to the interaction of cells with their surroundings and play an important role in determining functional responses. These receptors are integral membrane proteins responsible for the binding of extracellular signaling molecules and transduction into

• br Materials and methods br Results

  2022-06-17

  

  Materials and methods Results Discussion All the UDG superfamily glycosylases examined here, UDG, SMUG1, TDGFL, and TDG82−308, are capable of completely converting U-containing duplex substrates to product, though at different rates. Under STO conditions, kobs reflects the slowest kinetic s

• A oligomers increased ubiquitination of GLT in astrocytes Pr

  2022-06-17

  

  Aβ1-42 oligomers increased ubiquitination of GLT-1 in astrocytes. Previous studies found that astrocytic GLT-1 is internalized from the cell surface by ubiquitination of lysines located in the cytoplasmic C-terminus of the transporter (Gonzalez-Gonzalez et al., 2008, Martinez-Villarreal et al., 2012

• L Family Leguminosae widely distributed in tropical and

  2022-06-17

  

  L. (Family Leguminosae) widely distributed in tropical and subtropical regions of the world. As a medicinal and edible plant, it is widely used in Asia, especially in China, Korea, Japan and India. It was first recorded in Shen Nong Ben Cao Jing (神农本草经), and was described having the effect of cleari

• The regulation of gap junction connexin mediated activities

  2022-06-17

  

  The regulation of gap junction-connexin-mediated activities may be achieved through action on the channel gating properties (membrane voltage, pH, interaction with junctional and cytoskeletal proteins, Ca2+ and K+ concentrations, etc) or on the trafficking, turnover and localization of connexins. Sh

• Cell cell junction proteins were the

  2022-06-16

  

  Cell-cell junction proteins were the first upstream modules to be characterized as contact sensors through the Hippo pathway. These junctions may be divided in 2 categories: adherens and epithelial polarity junctions. The establishment of intercellular contacts involves the cadherin proteins present

• Given the major differences between the molecular regulation

  2022-06-16

  

  Given the major differences between the molecular regulation of the genes encoding HO-1 (HMOX1) in mice and humans, it is not appropriate to utilize mouse models for mechanistic analyses of human HMOX1[35]. In addition, it has been reported that drugs, such as statins, as well as stressors and the r

• FoxM a downstream target of Gli

  2022-06-16

  

  FoxM1, a downstream target of Gli, has been mainly related to Paxilline regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression (Wonsey & Fol

• br Funding This work was

  2022-06-16

  

  Funding This work was partially supported by the National Institute on Alcohol Abuse and Alcoholism, award R00AA021264, startup funds from the Department of Immunology, Herbert Wertheim College of Medicine, and the Office of Research and Economic Development at FIU, and pilot funds from Dr. Werth

• In the present study we showed that reduced neuron formation

  2022-06-16

  

  In the present study, we showed that reduced neuron formation in vitro induced by IL-1β was ameliorated by activation of GPR55 in both human and mouse cultures of NSCs. Pre-treatment with GPR55 agonists also blocked upregulation of inflammatory cytokine receptor mRNA (IL-1R1, IL-6st) while increasin

• Epidemiological studies revealed that vitamin D

  2022-06-16

  

  Epidemiological studies revealed that vitamin D deficiency was associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases, in particular, Alzheimer's and Parkinson's disease (Annweiler et al., 2013; Knekt et al., 2010), dementia and cognitive function impairment (Balio

• Fmoc-Val-OH After ischemia expression of transcription facto

  2022-06-16

  

  After ischemia, expression of transcription factors, including products of immediate early genes, stress proteins and neurotrophic factors are also altered in CA1 neurons78, 79. These proteins are potential candidates for downregulating of GluR2 expression by reducing mRNA transcription or stability

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