• On the other hand with the present study

  2018-10-31

  

  On the other hand, with the present study we verified that METH did not alter protein expression of cyclin inhibitors, p21 and p27, which suggests the involvement of other mechanisms in METH-induced cyclin E down-regulation. In fact, Heo et al. (2006) showed that blockade of MAPK pathway with PD-980

• CXCL has been previously identified

  2018-10-31

  

  CXCL12 has been previously identified as an estrogen-regulated gene in estrogen receptor (ER)-positive ovarian and breast cancer gnrh agonists (Jaerve et al., 2012). Here we show that in the endometrium, E2 significantly increased CXCL12 expression, suggesting a mechanism by which stem cells are re

• br Materials and methods br Results

  2018-10-31

  

  Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e

• The karyotype of the MPSII iPSC

  2018-10-31

  

  The karyotype of the MPSII-2.5 iPSC line was determined by Giemsa-banding, proving normal trpv1 antagonist 46, XY karyotype, without any detectable abnormalities (Fig. 1B). Materials and methods Acknowledgement We would like to thank the Department of Pediatrics, University of Pécs (Hungary)

• br Experimental Procedures br Acknowledgments

  2018-10-31

  

  Experimental Procedures Acknowledgments We would like to thank Dr. J.C. Louis (Amgen) for the CG4 cell line (Louis et al., 1992), Dr. J. Trotter (University of Mainz) for the Oli-neu cell line (Jung et al., 1995), J. Hightower for artwork, and Dr. M. Götz and members of the O.H. lab for valuab

• In the adult mouse and human lungs distinct

  2018-10-31

  

  In the adult mouse and human lungs, distinct region-specific epithelial progenitor cells have been described (Wansleeben et al., 2013), but their fetal counterparts remain undercharacterized. At E10.5–E12.5, Id2-expressing distal tip cells of the fetal lung buds are multipotent and contribute to the

• Most AB ECFCs were poorly

  2018-10-31

  

  Most AB-ECFCs were poorly clonogenic, entered rapidly in senescence and had limited functional capacities compared to CB-ECFCs. Moreover, their transcriptional level for the stemness genes DNMT3b, GDF3 and SOX2, that we have previously described (Guillevic et al., 2016), were similar to those found

• In summary our results revealed that loss of

  2018-10-31

  

  In summary, our results revealed that loss of Eva1a leads to impaired NSC self-renewal and differentiation, along with a decrease in autophagy, which is inversely associated with the activation of the PIK3CA/AKT-mTOR signaling. Functionally, EVA1A overexpression or MP treatment substantially rescued

• The inhibition of differentiation has

  2018-10-31

  

  The inhibition of differentiation has been considered to play a role in many types of tumor development through maintenance of the proliferating progenitor cell state. Previous studies demonstrated that the knockdown of EWS-FLI1 in Ewing sarcoma cell lines results in osteogenic, adipogenic and chond

• br Experimental Procedures br Author Contributions br

  2018-10-31

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported by JST, CREST and MEXT (to E.N.), and MEXT Scholarship Program (to J.L.). Introduction Developmental processes depend on highly orchestrated shifts in the levels of specific mRNAs. While regulation of t

• In relation to these twins the

  2018-10-30

  

  In relation to these twins the structure defects also perform the opposite function, acting as a stopper. When meeting an impassable stopper, the twinning dislocations halt and the detwinning process comes to an end. The fact that the amount of twins decreases with the load increase (see Fig. 6b) in

• Furthermore as much as nutritional well being is determined

  2018-10-30

  

  Furthermore, as much as nutritional well-being is determined by genetic predisposition and individual behaviour, it is also a matter of social justice. While the effects of inequality may appear relatively minor, they affect millions of Indonesians. An economic policy that promotes equity and qualit

• Finally gestation and early infancy are critical

  2018-10-30

  

  Finally, calcium channel blockers and early infancy are critical periods for health and overweight development in adolescence and adulthood (Currie & Almond, 2011; Dietz, 1994). To explore this association we ran models controlling for median income and mean education in the municipality at the time

• While our findings contribute to this relatively recent body

  2018-10-30

  

  While our findings contribute to this relatively recent body of work around multimorbidity across the life course, they should be interpreted in context. The NHIS is a nationally representative sample that allows a population-level examination of correlates of multimorbidity. The cross-sectional nat

• Research quantifying community capacity has identified stati

  2018-10-30

  

  Research quantifying metabolic enzymes capacity has identified statistically significant differences amongst neighbourhoods (Jung & Rhee, 2013) and between towns (Lovell et al., 2015a), thus confirming the importance of place to our social relationships. Place is recognised by geographers as those

15034 records 992/1003 page Previous Next First page 上5页 991992993994995 下5页 Last page