• br Mechanism of HH pathway activation in NSCLC

  2022-01-27

  

  Mechanism of HH pathway activation in NSCLC Despite the role of the HH pathway in basal cell carcinoma and medulloblastoma, it has been postulated that epithelial tumors do not demonstrate cell autonomous HH ligand activity. The main evidence comes from the study by Yauch et al showing no correla

• Stability of DBS over the day time points was

  2022-01-27

  

  Stability of DBS over the 60-day time points was encouraging, with a maximum of 0.1 log10 IU/mL degradation from the day 1 value (Supplementary Fig. 1 and Supplementary Table 3). Discussion This study evaluated the sensitivity and specificity of the Aptima HCV Dx assay for HCV RNA detection from

• To identify structurally novel autophagy inhibitors a medium

  2022-01-27

  

  To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 tnf alpha inhibitors stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be detected b

• Dormancy is a physiological state when viable seeds do not

  2022-01-27

  

  Dormancy is a physiological state when viable seeds do not germinate. Seed stratification, a commonly used technique, is used for dormancy removal and can be performed in moisture for an experimentally revealed time at warm or cold temperatures. All conditions depends on plant species (Dębska et al.

• Compounds and were tested for pharmacodynamic effects

  2022-01-27

  

  Compounds , and were tested for pharmacodynamic effects in a mouse oral glucose tolerance test (oGTT) in wild-type and GPR120 deficient mice, and each compound demonstrated GPR120 mechanism-based effects. Data for compound is shown in , indicating mechanism-based reduction in glucose excursion a

• The finding that GPR acts as a receptor

  2022-01-27

  

  The finding that GPR35 acts as a receptor for 2-acyl LPA is noteworthy, because P2Y5, which has homology with GPR35 (29%), has recently been shown to act as a receptor for 2-acyl LPA [14]. LPA3 is also a specific receptor for 2-acyl LPA [15]. It is also worth noting that GPR55, which has homology wi

• Ferrostatin-1 Niacin nicotinic acid is widely used to regula

  2022-01-27

  

  Niacin (nicotinic acid) is widely used to regulate abnormalities in plasma lipid and lipoprotein metabolism, as evidenced by its potential for reducing atherosclerotic cardiovascular disease risks (Guyton, 1998), due to its ability to reduce circulating triglycerides and apolipoprotein-B containing

• To examine the possible role

  2022-01-27

  

  To examine the possible role of mGluRs in the LH/PFA in the hypercapnic ventilatory response, a nonspecific antagonist of mGluRs, MCPG, was microinjected into the LH/PFA. MCPG elicited a significantly increased hypercapnic ventilatory response in awake rats, but not during sleep, in the light and da

• Increased expression of Glut is detected in

  2022-01-26

  

  Increased expression of Glut1 is detected in a number of cancer types including lung [7], brain [8], bladder [9], cervical [10], colorectal [11], esophageal [12], hepatocellular [13], head and neck [14], gastric [15], ovarian [16], renal cell [17], pancreatic [18], thyroid [19] and breast [20]. Over

• Peripheral injury or disease induced alterations in synaptic

  2022-01-26

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• The genes for the receptors for

  2022-01-26

  

  The genes for the receptors for peptides similar to glucagon are dispersed on three human chromosomes, with two on chromosome 17 (GCGR and GLP2R) and one each on chromosomes 6 (GLP1R) and 19 (GIPR) (see Table S1). The exon–intron gene structures of these genes are similar, as are the genes for other

• The schematic diagram of the antagonistic

  2022-01-26

  

  The schematic diagram of the antagonistic interactions of Zn2+ and neurosteroids (NSs) at GABA-A receptors is summarized in Fig. 7. Neurosteroids exhibit powerful seizure protective effects against experimental seizures probably through the potentiation of synaptic and extrasynaptic GABA-A receptor-

• acetylcholinesterase inhibitor At present many methods have

  2022-01-26

  

  At present, many methods have been applied for multiple detection. For example, acetylcholinesterase inhibitor [[9], [10], [11]] is frequently used to detect multiple targets because of its exquisite sensitivity and specificity, but it is difficult to design experiments to test short-length oligonuc

• A general synthesis of the tetrazole

  2022-01-26

  

  A general synthesis of the tetrazole is shown in . First, a magnesium-halogen exchange reaction quenched with DMF afforded benzo[]thiophene-5-carbaldehyde , which was further decorated with a bromine at the 3-position (). A Suzuki reaction with -tolylboronic AZD1208 followed by reduction of the al

• The current lack of effective treatments for

  2022-01-26

  

  The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th

15692 records 479/1047 page Previous Next First page 上5页 476477478479480 下5页 Last page