• Repulsive interactions towards undesirable substrates are ar

  2020-11-04

  

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and explo

• The development of novel approaches to study

  2020-11-04

  

  The development of novel approaches to study GPCR-mediated transactivation in live P005091 synthesis is important, and this study describes a unique BRET-based quantification of Grb2 recruitment to the EGFR as a direct readout of GPCR-mediated transactivation. We have previously used the recruitmen

• Mutation in BRCT II domain W

  2020-11-04

  

  Mutation in BRCT-II domain (W893R) either in the full-length context or the C-terminal context greatly reduced the expression of LIG4 (Fig. 2B, Fig. 3B), suggesting the importance of BRCT-II domain in the maintenance of LIG4. In this regard, it might be noted that LIG4 protein was undetectable in Li

• br Conclusion The present work

  2020-11-04

  

  Conclusion The present work describes the synthesis of 18 naphthoquinonolyl-1,2,3-triazole compounds based on natural product modification with antiplasmodial activity. Lapachol derivatives disclosed higher activity than the natural product. Six of these final modified lapachol 1,2,3-triazole com

• Mass spectrometry has previously been used to examine

  2020-11-04

  

  Mass spectrometry has previously been used to examine the presence of Hyp in recombinant collagen, using hydrolysates to identify the individual imino acid, equivalent to an amino INCB024360 analogue analysis [33], and also by analysis of mass changes to tryptic peptides [34]. The present study, ho

• More and more studies are focused

  2020-11-04

  

  More and more studies are focused on the function role of EPAC1 in cancer proliferation, apoptosis and migration. Recently, it was reported that the EPAC-ERK and AKT signaling pathways promote the B cell antigen receptor (BCR) mediated growth arrest and apoptosis in the B lymphoma cell line WEHI-231

• In conclusion we have shown that

  2020-11-04

  

  In conclusion, we have shown that the cellular effects produced by SFN in NSCLC iniparib are largely mediated by SFN-induced production of ROS. Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels prot

• Autophagy Compound Library The majority of APC C subunits

  2020-11-04

  

  The majority of APC/C subunits form a giant scaffold, which was originally named the arc lamp, based on its shape when viewing APC/C from one side (Figure 1 and Box 1) [24]. The scaffold consists of two modules: the TPR lobe resembles the curved post and lamp, and the platform resembles the Autophag

• Alpha SYN has no direct effect on forskolin

  2020-11-04

  

  Alpha-SYN has no direct effect on forskolin-induced CREB phosphorylation, but rather blocks the stimulation of CRE-mediated transcription in the nucleus. Previously we suggested that α-SYN can enter the nucleus and is present in both cytosolic and nuclear fractions without direct interaction between

• Besides degrading cholesterol the cholesterol degradation pa

  2020-11-03

  

  Besides degrading cholesterol, the cholesterol degradation pathway also offers a route to obtain useful starting materials for the production of steroid drugs and hormones. Indeed, steroids are among the most marketed pharmaceuticals with about 300 approved steroid drugs [15] and a worldwide market

• Based on our studies presented

  2020-11-03

  

  Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool Neochlorogenic acid as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new char

• Introduction Cyclin dependent kinases CDKs are

  2020-11-03

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as pterostilbene and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cycli

• We thank Dr Hongqiang Qin at

  2020-11-03

  

  We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr

• We further examined our hypothesis that the activation of CR

  2020-11-03

  

  We further examined our hypothesis that the activation of CRF and CCK systems is responsible for the enhanced anxiety-like behavior induced by immobilization stress using two antagonists to block the expression of CRF1 and CCK2 receptors. It was found that CCK2 receptor antagonist CR2945 or CRF1 ant

• Since its inception ADEPT approach has been widely

  2020-11-03

  

  Since its inception, ADEPT approach has been widely reported by many groups using a variety of enzymes and prodrugs (see reviews) [12], [14]. Both mammalian and non-mammalian enzymes have been utilised. Of the mammalian variety, human β-glucuronidase in combination with many prodrugs [17], [18] and

15730 records 740/1049 page Previous Next First page 上5页 736737738739740 下5页 Last page