• The ESC update emphasizes the need

  2020-10-22

  

  The 2017 ESC update emphasizes the need for implementing strategies to minimize PCI-related complications, including risk stratification for ischemia and bleeding, keeping triple antithrombotic therapy to the shortest possible duration with dual antithrombotic therapy as an alternative, using non–vi

• In rodents Wang et al Wang and Tsirka b

  2020-10-22

  

  In rodents (Wang et al., 2003, Wang and Tsirka, 2005b, Zhu et al., 2012) and humans (Wang et al., 2011), the major forms of cell death after ICH are necrosis and apoptosis. In the perihematomal region of rodents, the number of necrotic and apoptotic cells peaks at 72h post-ICH (Matsushita et al., 20

• On the opposite side sPLA X has also been implicated

  2020-10-22

  

  On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer FH1 and promotes their survival during nutrient stress. It acts through the products of its enzymatic act

• A range of inhibitors were therefore synthesized containing

  2020-10-22

  

  A range of inhibitors were therefore synthesized containing either carboxylic voltage gated potassium channel or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, respe

• P falciparum DHFR TS is a particularly

  2020-10-22

  

  P. falciparum DHFR-TS is a particularly important enzyme, because it is from the protozoan species that is associated with most malaria infections. Since this enzyme is responsible for catalyzing sequential reactions in the thymidylate cycle, its inhibition slows malarial dTMP production and therefo

• Recently Schenck et al identified an active site asparagine

  2020-10-22

  

  Recently, Schenck et al. [25] identified an active site asparagine 222 (N222) residue in the Glycine max TyrAp/PDH (GmPDH1) that is responsible for its prephenate substrate specificity. Mutating the single N222 into an acidic residue (i.e. aspartate, D) in the legume TyrAp/PDH shifted from prephenat

• br NF B and STAT as

  2020-10-22

  

  NF-κB and STAT as Regulators of the CDK System While current data support the concept that CDKs augment the proinflammatory activity of NF-κB, our understanding of the function of this transcription factor system in CDK regulation remains patchy. Seminal studies showed the contribution of NF-κB t

• In recent years neuroimaging studies have increasingly demon

  2020-10-22

  

  In recent years, neuroimaging studies have increasingly demonstrated acute effects of THC on 1,2-Dimyristoyl-sn-glycerol mg function, the vast majority of them involving a cognitive challenge (Bossong et al., 2014b). For example, without affecting performance accuracy, THC caused reductions in activ

• Furthermore certain components in the Melanocyte Growth Medi

  2020-10-22

  

  Furthermore, certain components in the Melanocyte Growth Medium seem to influence the response to UV radiation [17]: UV-induced effects on tyrosinase activity were less distinct in melanocytes cultured with phorbol 12-myristate 13-acetate [18], which was also an ingredient in our Melanocyte Growth M

• Williamson et al interrogated the fusion

  2020-10-22

  

  Williamson et al. [30] interrogated the fusion gene status of 210 appropriately reviewed and annotated RMS specimens divided into three groups: ERMS (n=77); fusion gene-positive ARMS (n=94); and fusion gene-negative ARMS (n=39), the latter comprising a group of tumor samples that appeared histologic

• Illumina for 1 ng DNA Estrogen receptor related receptor ERR

  2020-10-22

  

  Estrogen receptor-related receptor γ (ERRγ), like other members of the ERR subfamily, is a constitutively active orphan nuclear receptor, though unlike ERRα and β, it is more selectively expressed in metabolically active and highly vascularized tissues such as heart, kidney, brain, and skeletal musc

• ROS generation is crucial for NETs release upon both

  2020-10-22

  

  ROS generation is crucial for NETs release upon both physiological or pathogenic stimuli [16,30]. In our study, we further verified this conclusion by demonstrating that SRA stimulation by Poly I enhanced intracellular ROS levels while scavenging of ROS by anti-oxidant agents effectively abolished t

• The indigenous populations living at high mountain regions o

  2020-10-22

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human homoharringtonine to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary and h

• In contrast a single instillation of

  2020-10-22

  

  In contrast, a single instillation of BLM results in a progression of inflammatory events that culminates in marked remodeling of the lung interstitium. This process takes 2–3 weeks, with the fibrotic lesions becoming most pronounced within the first month [9]. Consequently, the BLM model offers the

• br Materials and methods br

  2020-10-22

  

  Materials and methods Results Discussion Studies have suggested that the Hh signaling pathway, which plays as an essential autocrine viability factor for MFBs [10], [11], is a potential therapeutic target for liver fibrosis. Previously reported works have proven the effectiveness of the Hh

15692 records 746/1047 page Previous Next First page 上5页 746747748749750 下5页 Last page