• The DNA damage response DDR is

  2020-09-11

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as daunorubicin regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been reco

• In general the DNMT encompass three different structural reg

  2020-09-11

  

  In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated

• Resistance to SP is linked to point mutations that accumulat

  2020-09-10

  

  Resistance to SP is linked to point mutations that accumulate at several sites in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) amiodarone hcl of P. falciparum (Roper et al., 2003). These mutations have been identified in codons 16, 51, 59, 108, and 164 in the dhfr gene and

• The proposed FDIR technique is presented in the following fo

  2020-09-10

  

  The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the selinexor environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estimated is p

• Due to the results of the experiment

  2020-09-10

  

  Due to the results of the experiment we decided to deploy our cloud service infrastructure with two platform-independent servers instead of one or three. This decision was based on two factors: (a) the use of more than one server is useful to avoid a bottleneck in the system, and (b) using more than

• br Objectives br Study design Thirty

  2020-09-10

  

  Objectives Study design Thirty KTx recipients were enrolled in this pilot study from December 2015 to May 2016. Patient demographics are presented in Table 1. The inclusion criteria were: age ≥ 18 years and CMV-IgG serostatus (D+/R−, D+/R+, D−/R+) pre-Tx. All patients were enrolled during the

• Previous studies have documented that SCFAs may elicit effec

  2020-09-10

  

  Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero

• OxLDL down regulates eNOS and up regulates iNOS

  2020-09-10

  

  OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial Ro 48-8071 [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iNOS-mediated IRE

• The discoidin domain receptors DDR and DDR are receptor tyro

  2020-09-10

  

  The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases (RTKs) that are stimulated by collagen in the extracellular matrix (ECM). Unlike most other RTKs, they form ligand-independent stable dimers that are non-covalently linked. This ECM activation induces receptor phosphorylati

• ARA metabolites which are produced through

  2020-09-10

  

  ARA metabolites, which are produced through cytochrome P450 (CYP450) enzymes influence cardiovascular homeostasis. Human CYP4A11 and CYP1A2 metabolize ARA to 20-hydroxyecostearonic DL-TBOA australia (20-HETE) [11], which is a vasoconstrictor [12], platelet activator [13] and naturetic in the kidney

• Published results have revealed relationships

  2020-09-10

  

  Published results have revealed relationships between serine 81 in AR and some CDKs, especially CDKs 1, 5 and 9 [12], [13], [14], [15], [16]. These results are often supported by pharmacological inhibition of a certain CDK. An effect of CDK1 inhibition on suppression of S81-phosphorylation was previ

• This study evaluated the role

  2020-09-10

  

  This study evaluated the role of SERT in classical fear conditioning using a SERT knockout rat model. We found a clear disruption of cue-conditioned fear in SERT−/− rats, as measured with the fear-potentiated startle. This disruption was due to a deficit in fear acquisition and was accompanied by de

• Taking into account that a PFOS inhibits CRF gene expression

  2020-09-10

  

  Taking into account that: (a) PFOS inhibits CRF gene expression as well as CRF and corticosterone secretion (Pereiro et al., 2014); (b) CRF1r mediates the stimulation of the pituitary ACTH secretion by this neuropeptide (Rivier et al., 2003); (c) corticosterone regulates its own synthesis by a nega

• We further correlated OPRK and

  2020-09-10

  

  We further correlated OPRK1 and OPRM1 methylation levels with individual characteristics in Xinjiang Han and Uygur controls. Partial correlation analyses showed that OPRK1 methylation was positively correlated with age in Uygur male controls (r=0.72, p=0.001, adjusted by body mass index (BMI), gluco

• To evaluate the new quadrupolar CPA qCPA

  2020-09-10

  

  To evaluate the new quadrupolar CPA (qCPA) the pure fluid properties of CO2 are predicted both in the critical region and in the compressed liquid region. The model is furthermore applied for the prediction and correlation of binary mixtures with CO2 and n-alkanes, water, alcohols and a few quadrupo

15730 records 766/1049 page Previous Next First page 上5页 766767768769770 下5页 Last page