• In many studies spatial and temporal expression and subcellu

  2020-04-09

  

  In many studies, spatial and temporal expression and subcellular localizations of the DNMTs are examined in greater detail. These studies are evaluated and discussed in the remaining part of the article. DNMT1 protein expression was characterized in the genital ridge of the primitive mouse gonad at

• Increased knowledge about CRC pathogenesis has

  2020-04-08

  

  Increased knowledge about CRC pathogenesis has provided new and remarkable treatments beyond the classical options of surgery, radiation and chemotherapy [11]. Despite these advances, chemotherapy remains the most important element of anti-cancer therapy. Chemotherapy, when initiated, is generally e

• 133 2 br Introduction Analyses of genomic alterations

  2020-04-08

  

  Introduction Analyses of genomic alterations in cancer have identified epidermal growth factor receptor (EGFR) as one of the most potent “oncogenic driver” kinases that is present in many epithelial tumors including endometrial, breast, prostate, skin, esophagus, lung, stomach, colorectal, and re

• Many studies have shown that curcumin delays the progression

  2020-04-07

  

  Many studies have shown that curcumin delays the progression of atherosclerosis in different atherosclerotic animal models [18], [19], [20], [37] and the risk of atherosclerosis in human studies [15], [38], [39]. Curcumin also has many properties that contribute to combat atherosclerosis, such as an

• Although PKC in cancer cells is known to promote

  2020-04-07

  

  Although PKCδ in cancer Iberiotoxin is known to promote antiapoptotic signaling, a cleaved form of PKCδ, δCF, has been reported to play a contrasting role in enhancing apoptosis (Reyland, 2007), and these complex functions appear to be cell-type dependent (Basu and Pal, 2010). In NSCLC, full-length

• br Deubiquitination deubiquitinases and cancer

  2020-04-07

  

  Deubiquitination, deubiquitinases and cancer Protein deubiquitination is reverse process of ubiquitination and performed by deubiquitinases or deubiquitinating enzymes (DUBs), which help in removal of ubiquitin from target proteins and involve in ubiquitin maturation, recycling and editing (Pfoh

• wee1 br Material and methods br Results

  2020-04-07

  

  Material and methods Results Discussion In vitro evidence indicates that LAS191859 is a potent CRTh2 antagonist as demonstrated in GTPγS binding studies with potency in the low nanomolar range and in addition it demonstrates a long receptor residence time. This potency is also maintained in

• In addition to providing substantial insight into

  2020-04-07

  

  In addition to providing substantial insight into substrate recognition, structural studies have revealed important details about mechanisms of glycosylation and HCF-1 cleavage [28,30,33]. Activation of the nucleotide-sugar is accomplished through interactions of the β-phosphate with the N-terminus

• Enterobacteriaceae are gram negative rods that

  2020-04-07

  

  Enterobacteriaceae are gram negative rods that include the Escherichia coli and Shigella. There are several DNA ligases posted on the GenBank belong mostly to Enterobacteria phages, such as the T4 bacteriophage [30]. There are several protein markers used to differentiate between T4 phage superfamil

• In Hevea brasiliensis both the soluble

  2020-04-07

  

  In Hevea brasiliensis, both the soluble PPase and the membrane-bound V-PPase are present in the latex; the soluble PPase is in the C-serum (cytosol) of the latex [6] and the V-PPase is on the tonoplast of the lutoid, a special vacuole in the laticifers of rubber trees [7]. The V-PPase on the lutoid

• br Methods br Results br

  2020-04-07

  

  Methods Results Discussion The lowest intra-CeA dose of R278995/CRA0450 that prevented the elevations in palbociclib sale reward thresholds associated with nicotine withdrawal was 0.05μg/side (0.1μg total bilateral dose). The total bilateral dose in the present study is 100 times lower than

• Enzyme mimics belong to a type of

  2020-04-06

  

  Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a

• For this study we have used

  2020-04-06

  

  For this study we have used the intermediate affinity mutant antigen HEL2× for immunization. However, we have observed a similar defect in the plasmablast differentiation of EBI2-deficient SWHEL ONX0914 over a 10,000-fold affinity range by using WT HEL or the low-affinity mutant HEL3× (data not sho

• The majority of APC C subunits form a giant scaffold

  2020-04-06

  

  The majority of APC/C subunits form a giant scaffold, which was originally named the arc lamp, based on its shape when viewing APC/C from one side (Figure 1 and Box 1) [24]. The scaffold consists of two modules: the TPR lobe resembles the curved post and lamp, and the platform resembles the Benzamil

• br Experimental section br Results br Discussion In

  2020-04-06

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised 3230 did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by alter

15692 records 833/1047 page Previous Next First page 上5页 831832833834835 下5页 Last page