• br Funding This work was

  2018-10-20

  

  Funding This work was partially supported by grants from: ERC-2013 AdG MUNCODD GA340172, AriSLA full grant 2014ARCI, Epigen Flagship Project EPIGENOMICS, AFM TelethonGA17835, Fondazione Roma and Parent Project to I.B. Conflict of interest Author contributions Acknowledgments Introduct

• br Materials and methods br Acknowledgements This study

  2018-10-20

  

  Materials and methods Acknowledgements This study was supported by the European Union within the 7th European Community Framework Programme through funding for the NEUROMICS network (F5-2012-305121 to L.S.), the Marie Curie International Outgoing Fellowship (grant PIOF-GA-2012-326681 to R.S. a

• We also found clear differences in the

  2018-10-20

  

  We also found clear differences in the amount of stress fibers between the perivascular derivatives. Abundant stress fibers were found in con-vSMCs located throughout the entire cell body. While hiPSC syn-vSMCs had fewer stress fibers, pericyte derivatives demonstrated the lowest levels of stress fi

• No effective therapies are available

  2018-10-20

  

  No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS nuci

• The functional specificity of ECs forming the microcirculati

  2018-10-20

  

  The functional specificity of ECs forming the microcirculation of organs has long been appreciated and recently defined molecularly by Nolan et al. (2013). The characterization of the KDR+ endoderm cell-derived ECs generated in mouse and hESC cultures suggests that those are the specialized sinusoid

• Introduction The NOD SCID Il r NSG

  2018-10-20

  

  Introduction The NOD.SCID Il2rγ (NSG) mouse strain dramatically improved investigators’ ability to study human hematopoietic stem cell (HSC) engraftment (Rongvaux et al., 2013; Shultz et al., 2005). The NSG strain combines a series of mutations that inhibit the host’s immune system by different mec

• Transplantation of iPSC NSCs within the neonatal

  2018-10-20

  

  Transplantation of iPSC-NSCs within the neonatal cyclooxygenase pathway yielded stable engraftment across the neuroaxis for at least 4 months, but only within and adjacent to white matter tracts. Although the precise mechanisms are unclear, NSCs from various sources display a tropism for white matte

• br Materials and Methods br Results br

  2018-10-20

  

  Materials and Methods Results Discussion The importance of bone marrow microenvironment in leukemogenesis becomes more evident each day. Kim and colleagues described the ability of leukemic stem order LY-411575 to reset the communication between hematopoietic stem cells and the bone marrow

• Several previous studies support the possibility that RPC

  2018-10-20

  

  Several previous studies support the possibility that RPC differentiation into podocytes may be involved in remission of different types of diseases, including proliferative glomerulonephritis (Rizzo et al., 2013), gestational pre-eclampsia (Penning et al., 2014), and diabetic nephropathy (Pichaiwon

• In this study we describe an efficient dCas activator

  2018-10-20

  

  In this study, we describe an efficient dCas9 activator with multimeric VP16 activation domain and a simplified method for guide RNA assembly and cloning. We demonstrate that the dCas9 activator can be fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) (Iwamoto et al., 201

• During development extrinsic signals in a progenitor s

  2018-10-20

  

  During development, extrinsic signals in a progenitor’s microenvironment provide cues for self-renewal and lineage commitment. Although several growth factors, including fibroblast growth factors (FGFs) 2 (Perantoni et al., 1995), 8 (Perantoni et al., 2005), 9, and 20 (Barak et al., 2012) and epider

• All PGCs differentiated from ESCs

  2018-10-20

  

  All PGCs differentiated from ESCs in our study, regardless of differentiation approach or sorting strategy, were capable of implementing ICC erasure at the Snprn ICC. However, unlike E9.5 PGCs from the embryo, the hypomethylated state at this ICC was unstable, and in every case re-methylation was in

• Collectively we have evaluated the impact of

  2018-10-20

  

  Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to

• Numerous morphogenetic events are explained by the cell surf

  2018-10-20

  

  Numerous morphogenetic events are explained by the cell surface tension model. In equilibrium, surface tension is minimized via coordinated forces generated by cell surface tension and actomyosin-mediated cortical tension, resulting in cell sorting and self-organization (Beysens et al., 2000; Heisen

• inhibitor of apoptosis TPCA reversibly binds to IKK and prev

  2018-10-20

  

  TPCA-1 reversibly binds to IKKβ and prevents it from phosphorylating IκBα for degradation and thereby blocks nuclear translocation of NF-κB (Kondo et al., 2008). Our results demonstrate that TPCA-1 may inhibit the stimulatory action of TNF-α on NF-κB. TPCA-1 partially inhibits secretion of constitut

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